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hdpp4 transgenic mice  (Gilead Sciences)

 
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    Gilead Sciences hdpp4 transgenic mice
    Hdpp4 Transgenic Mice, supplied by Gilead Sciences, used in various techniques. Bioz Stars score: 99/100, based on 14746 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/hdpp4+transgenic+mice/pmc09122840-270-3-6?v=Gilead+Sciences
    Average 99 stars, based on 14746 article reviews
    hdpp4 transgenic mice - by Bioz Stars, 2026-07
    99/100 stars

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    hdpp4 transgenic mice  (Gilead Sciences)
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    Gilead Sciences hdpp4 transgenic mice
    The three inactivated MERS-CoV induced a protective immune response against MERS-CoV infection in the <t>hDPP4-transgenic</t> mouse model. ( A ) Changes in body weight and survival rate were monitored for two weeks after MERS-CoV infection. The survival symbols of H 2 O 2 -MERS-CoV and BEI-MERS-CoV overlapped with FA-MERS-CoV. ( B ) MERS-CoV specific neutralizing antibodies (nAbs) and ( C , D ) S1 protein-specific serum IgG/IgG2c/IgG1 levels were measured for two weeks after the third immunization. ( E ) MERS-CoV titers in lung and brain tissues were observed by plaque assay on dpi 4 and 8 after the MERS virus challenge. Data are represented as the mean ± S.E.M. *** p < 0.001 compared with alum only. ### p < 0.001, #### p < 0.0001 compared with alum only lung. † p < 0.05, †††† p < 0.00001 compared with alum only brain.
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    The three inactivated MERS-CoV induced a protective immune response against MERS-CoV infection in the hDPP4-transgenic mouse model. ( A ) Changes in body weight and survival rate were monitored for two weeks after MERS-CoV infection. The survival symbols of H 2 O 2 -MERS-CoV and BEI-MERS-CoV overlapped with FA-MERS-CoV. ( B ) MERS-CoV specific neutralizing antibodies (nAbs) and ( C , D ) S1 protein-specific serum IgG/IgG2c/IgG1 levels were measured for two weeks after the third immunization. ( E ) MERS-CoV titers in lung and brain tissues were observed by plaque assay on dpi 4 and 8 after the MERS virus challenge. Data are represented as the mean ± S.E.M. *** p < 0.001 compared with alum only. ### p < 0.001, #### p < 0.0001 compared with alum only lung. † p < 0.05, †††† p < 0.00001 compared with alum only brain.

    Journal: Vaccines

    Article Title: Comparing the Immunogenicity and Protective Effects of Three MERS-CoV Inactivation Methods in Mice

    doi: 10.3390/vaccines10111843

    Figure Lengend Snippet: The three inactivated MERS-CoV induced a protective immune response against MERS-CoV infection in the hDPP4-transgenic mouse model. ( A ) Changes in body weight and survival rate were monitored for two weeks after MERS-CoV infection. The survival symbols of H 2 O 2 -MERS-CoV and BEI-MERS-CoV overlapped with FA-MERS-CoV. ( B ) MERS-CoV specific neutralizing antibodies (nAbs) and ( C , D ) S1 protein-specific serum IgG/IgG2c/IgG1 levels were measured for two weeks after the third immunization. ( E ) MERS-CoV titers in lung and brain tissues were observed by plaque assay on dpi 4 and 8 after the MERS virus challenge. Data are represented as the mean ± S.E.M. *** p < 0.001 compared with alum only. ### p < 0.001, #### p < 0.0001 compared with alum only lung. † p < 0.05, †††† p < 0.00001 compared with alum only brain.

    Article Snippet: The 6-week-old female hDPP4 (C57BL/6 with human DPP4) transgenic mice were provided by Macrogen (Seoul, Korea) and were maintained in an ABSL-3 facility at the KDCA.

    Techniques: Infection, Transgenic Assay, Plaque Assay, Virus